Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Altered immune landscape of cervical lymph nodes reveals Epstein-Barr virus signature in multiple sclerosis

21 Feb 2025

Abstract excerpt

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, and Epstein-Barr virus (EBV) infection is a prerequisite for developing the disease. However, the pathogenic mechanisms that lead to MS remain to be determined. Here, we characterized the immune landscape of deep cervical lymph nodes (dcLNs) in newly diagnosed untreated patients with MS (pwMS) using fine-needle aspirations. By...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immunotherapy and Immune Responses
Share to Multiple Sclerosis Research Studies
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39982975
DOI: 10.1126/sciimmunol.adl3604

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Altered immune landscape of cervical lymph nodes reveals Epstein-Barr virus signature in multiple sclerosisPMID 39982975Read ↗

Single-cell analysis suggests coordinated immune-cell redistribution between blood and cerebrospinal fluid in early multiple sclerosisSemantic proximity Read ↗

Antigen-resolved remodeling of EBV-specific CD8⁺ T cell immunity in multiple sclerosisSemantic proximity Read ↗

A pathogenic and clonally expanded B cell transcriptome in active multiple sclerosisSemantic proximity Read ↗

Enhanced EBNA2-dependent activity in EBV-transformed B cells from patients with multiple sclerosisSemantic proximity Read ↗

Intrathecally expanded GZMK+/GZMH+ CD8 T cells targeting EBV antigens may reduce severity of Multiple SclerosisSemantic proximity Read ↗

Integrated single cell transcriptomics of cerebrospinal fluid cells in early Multiple SclerosisSemantic proximity Read ↗

Defining the architecture of cerebrospinal fluid cellular communities in neuroinflammatory diseasesSemantic proximity Read ↗

Extracellular vesicles from wild-type Epstein–Barr virus–transformed B-cells export host DNA and EBV EBER1Semantic proximity Read ↗

Epstein-Barr virus is present in the brain of most cases of multiple sclerosis and may engage more than just B cellsSemantic proximity Read ↗

Spatial transcriptomics of compartmentalised inflammation in multiple sclerosisSemantic proximity Read ↗

The CD8 T Cell-Epstein-Barr Virus-B Cell Trialogue: A Central Issue in Multiple Sclerosis PathogenesisSemantic proximity Read ↗

Expression profiling of cerebrospinal fluid identifies dysregulated antiviral mechanisms in multiple sclerosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.