Genome-wide identification and functional validation of the WW domain containing oxidoreductase gene associated with sleep duration.

doi:10.1038/s41598-024-81158-8

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Article

Genome-wide identification and functional validation of the WW domain containing oxidoreductase gene associated with sleep duration.

Scientific reports - 14 Feb 2025

Kim Soriul, Kang So Who, Kim Song E, Kim Hyeon Jin, Kim Sol Ah, Lee Yae Won, Kim Eun Young, Shin Chol, Lee Hyang Woon

Abstract excerpt

Individual differences in sleep duration have been reported, and genetic components of sleep duration have been identified showing various heritability. To identify genetic variants that contribute to sleep duration, we conducted a human genome-wide identification on sleep duration and performed confirmatory experiments using a Drosophila model. Genome-wide association study in human was analyzed to determine the...

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Topics

Humans
Genome-Wide Association Study
Sleep
Polymorphism, Single Nucleotide
Animals
Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

WW Domain-Containing Oxidoreductase

Female

Adult

Middle Aged

Tumor Suppressor Proteins

Drosophila

Sleep Duration

Source

Open in PubMed Open full text

Identifiers

PMID: 39952983
DOI: 10.1038/s41598-024-81158-8
PMCID: PMC11828923

Genes

WWOX

Provenance

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