Article
Selection for long and short sleep duration in Drosophila melanogaster reveals the complex genetic network underlying natural variation in sleep.
PLoS genetics - 1 Dec 2017
Harbison Susan T, Serrano Negron Yazmin L, Hansen Nancy F, Lobell Amanda S
Abstract excerpt
Why do some individuals need more sleep than others? Forward mutagenesis screens in flies using engineered mutations have established a clear genetic component to sleep duration, revealing mutants that convey very long or short sleep. Whether such extreme long or short sleep could exist in natural populations was unknown. We applied artificial selection for high and low night sleep duration to an outbred...
Topics
- Animals
- Drosophila Proteins
- Drosophila melanogaster
- ErbB Receptors
- Female
- Gene Frequency
- Gene Regulatory Networks
- Intracellular Signaling Peptides and Proteins
- Male
- Mitogen-Activated Protein Kinases
- Mutagenesis
- Mutation
- Phenotype