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Article

PPAR-<b><i>γ</i></b>Regulates Trophoblast Differentiation in the BeWo Cell Model

1 Jan 2014

Abstract excerpt

Common pregnancy complications, such as severe preeclampsia and intrauterine growth restriction, disrupt pregnancy progression and impair maternal and fetal wellbeing. Placentas from such pregnancies exhibit lesions principally within the syncytiotrophoblast (SCT), a layer in direct contact with maternal blood. In humans and mice, glial cell missing-1 (GCM-1) promotes differentiation of underlying cytotrophoblast...

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PMID: 24711815
DOI: 10.1155/2014/637251

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