Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phillyrin regulates the JAK2/STAT3 signaling pathway by inhibiting TOP2A expression to accelerate ferroptosis in hepatocellular carcinoma

12 Feb 2025

Abstract excerpt

Despite advancements and refinements in the therapeutic approaches for hepatic malignancies, liver cancer remains a prevalent and deadly form of cancer, with its grim outlook posing as a significant clinical challenge. Phillyrin (PHN) has been reported to have anticancer effects, but the anticancer mechanism in liver cancer is ominous. By searching the potential target of PHN in the online database and liver...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ferroptosis and cancer prognosis
Share to MicroRNA in disease regulation
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39950325
DOI: 10.3892/or.2025.8876

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phillyrin regulates the JAK2/STAT3 signaling pathway by inhibiting TOP2A expression to accelerate ferroptosis in hepatocellular carcinomaPMID 39950325Read ↗

Bioinformatics analysis of genes related to ferroptosis in hepatic ischemia-reperfusion injurySemantic proximity Read ↗

Highly expressed RPLP2 inhibts ferroptosis to promote hepatocellular carcinoma progression and predicts poor prognosisSemantic proximity Read ↗

Study on the effects of Polyphyllin I and Curcumin on liver cancer based on the cross-action of ferroptosis and energy metabolismSemantic proximity Read ↗

A novel antitumor mechanism of triptonide in colorectal cancer: inducing ferroptosis via the SLC7A11/GPX4 axisSemantic proximity Read ↗

GINS4 suppresses ferroptosis by antagonizing p53 acetylation with SnailSemantic proximity Read ↗

DNA topoisomerase 1 and 2A function as oncogenes in liver cancer and may be direct targets of nitidine chlorideSemantic proximity Read ↗

HTRA1 interacts with SLC7A11 to modulate colorectal cancer chemosensitivity by inhibiting ferroptosisSemantic proximity Read ↗

SNAI2 promotes the development of ovarian cancer through regulating ferroptosisSemantic proximity Read ↗

TanshinoneIIA exerts protective effects via attenuate FTH1, a biomarker and therapeutic target in head and neck Squamous Cell CarcinomaSemantic proximity Read ↗

Identification and functional analysis of the hub Ferroptosis-Related gene EZH2 in diabetic kidney diseaseSemantic proximity Read ↗

Trifluridine/tipiracil induces ferroptosis by targeting p53 via the p53-SLC7A11 axis in colorectal cancer 3D organoidsSemantic proximity Read ↗

CRISPR/Cas9 screening reveals that ASB2 inhibits p53-dependent ferroptosis to mediates Lenvatinib resistance in hepatocellular carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.