Five-Year (2017-2022) Evolutionary Dynamics of Human Coronavirus HKU1 in Southern France With Emergence of Viruses Harboring Spike H512R Substitution.

doi:10.1002/jmv.70217

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Article

Five-Year (2017-2022) Evolutionary Dynamics of Human Coronavirus HKU1 in Southern France With Emergence of Viruses Harboring Spike H512R Substitution.

Journal of medical virology - 1 Feb 2025

Hikmat Houmadi, Le Targa Lorlane, Boschi Céline, Py Justine, Morand Aurélie, Lagier Jean-Christophe, Aherfi Sarah, Fantini Jacques, La Scola Bernard, Colson Philippe

Abstract excerpt

HCoV-HKU1 diversity and evolution were scarcely studied. We performed next-generation sequencing (NGS) and analysis of HCoV-HKU1 genomes over 5 years. NGS used Illumina technology on NovaSeq 6000 following whole genome PCR amplification by an in-house set of primers designed using Gemi and PrimalScheme. Genome assembly and analyses used CLC Genomics, Mafft, BioEdit, Nextstrain, Nextclade, MEGA, and iTol...

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Topics

Humans
Spike Glycoprotein, Coronavirus
Evolution, Molecular
Genome, Viral
Amino Acid Substitution

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

SARS-CoV-2

France

Genotype

Phylogeny

High-Throughput Nucleotide Sequencing

COVID-19

Molecular Dynamics Simulation

Source

Open in PubMed Open full text

Identifiers

PMID: 39949218
DOI: 10.1002/jmv.70217
PMCID: PMC11826117

Genes

CLC
TMPRSS2

Provenance

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