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Article

Gene-Environment Interaction Between CYP1B1 and Oral Contraception on Frontal Fibrosing Alopecia.

JAMA dermatology - 1 Jul 2024

Rayinda Tuntas, McSweeney Sheila M, Christou Evangelos, Ung Chuin Ying, Fenton David A, McGrath John A, Dand Nick, Simpson Michael A, Tziotzios Christos

Abstract excerpt

Importance: Frontal fibrosing alopecia (FFA) is an increasingly prevalent form of follicular lichen planus, causing irreversible hair loss predominantly in postmenopausal individuals. An earlier genome-wide meta-analysis of female FFA identified risk loci in genes implicated in self-antigen presentation and T-cell homeostasis, including HLA-B*07:02, ST3GAL1, and SEMA4B. However, CYP1B1, which is important for...

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Identifiers

PMID: 38809548
DOI: 10.1001/jamadermatol.2024.1315
PMCID: PMC11137654

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