Article
Using genetics to test the causal relationship of total adiposity and periodontitis: Mendelian randomization analyses in the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium.
International journal of epidemiology - 1 Apr 2015
Shungin Dmitry, Cornelis Marilyn C, Divaris Kimon, Holtfreter Birte, Shaffer John R, Yu Yau-Hua, Barros Silvana P, Beck James D, Biffar Reiner, Boerwinkle Eric A, Crout Richard J, Ganna Andrea, Hallmans Goran, Hindy George, Hu Frank B, Kraft Peter, McNeil Daniel W, Melander Olle, Moss Kevin L, North Kari E, Orho-Melander Marju, Pedersen Nancy L, Ridker Paul M, Rimm Eric B, Rose Lynda M, Rukh Gull, Teumer Alexander, Weyant Robert J, Chasman Daniel I, Joshipura Kaumudi, Kocher Thomas, Magnusson Patrik K E, Marazita Mary L, Nilsson Peter, Offenbacher Steve, Davey Smith George, Lundberg Pernilla, Palmer Tom M, Timpson Nicholas J, Johansson Ingegerd, Franks Paul W
Abstract excerpt
BACKGROUND: The observational relationship between obesity and periodontitis is widely known, yet causal evidence is lacking. Our objective was to investigate causal associations between periodontitis and body mass index (BMI). METHODS: We performed Mendelian randomization analyses with BMI-associated loci combined in a genetic risk score (GRS) as the instrument for BMI. All analyses were conducted within the...
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