Article
Viral Infection of Tumors Overcomes Resistance to PD-1-immunotherapy by Broadening Neoantigenome-directed T-cell Responses.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Oct 2015
Woller Norman, Gürlevik Engin, Fleischmann-Mundt Bettina, Schumacher Anja, Knocke Sarah, Kloos Arnold M, Saborowski Michael, Geffers Robert, Manns Michael P, Wirth Thomas C, Kubicka Stefan, Kühnel Florian
Abstract excerpt
There is evidence that viral oncolysis is synergistic with immune checkpoint inhibition in cancer therapy but the underlying mechanisms are unclear. Here, we investigated whether local viral infection of malignant tumors is capable of overcoming systemic resistance to PD-1-immunotherapy by modulating the spectrum of tumor-directed CD8 T-cells. To focus on neoantigen-specific CD8 T-cell responses, we performed...
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