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Massively parallel sequencing of a forensic combined panel of 107-plex STR loci and 292-plex SNP loci in the Han Chinese population.

Forensic science international. Genetics - 1 Mar 2025

Sun Weifen, Dong Bonan, Chu Xufeng, Xu Qiannan, Li Hui, Chen Man, Jiang Lei, Huang Ao, Zhu Bofeng, Liu Xiling

Abstract excerpt

Massively parallel sequencing (MPS), a well-established strategy for forensic DNA profiling, enables the simultaneous sequencing of multiple targeted loci of multiple samples at a single-base resolution with high coverage. In this study, we developed a novel typing system by combining solution-based hybrid capture methods with MPS to target as many as 107 short tandem repeats (STRs) and 292 single nucleotide...

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PMID: 39922092
DOI: 10.1016/j.fsigen.2025.103235

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