Article
Novel risk loci encompassing genes influencing STAT3, GPCR, and oxidative stress signaling are associated with co-morbid GERD and COPD.
PLoS genetics - 1 Feb 2025
Wilson Ava C, Rocco Alison, Chiles Joe, Srinivasasainagendra Vinodh, Labaki Wassim, Meyers Deborah, Hidalgo Bertha, Irvin Marguerite R, Bhatt Surya P, Tiwari Hemant, McDonald Merry-Lynn
Abstract excerpt
Chronic obstructive pulmonary disease (COPD) is a leading cause of death globally. Gastroesophageal reflux disease (GERD) is a common comorbidity in COPD associated with worse pulmonary symptoms, reduced quality of life, and increased exacerbations and hospitalizations. GERD treatment in COPD is associated with a lower risk of exacerbations and mortality; however, it is not clear whether these findings can be...
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