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The ALOX5 inhibitor zileuton promotes sunitinib resistance in renal cell carcinoma by reprogramming lipid metabolism

2026-05-15

Abstract excerpt

<title>Abstract</title> <p>Objective To investigate the molecular mechanisms of lipid metabolic reprogramming promoting tyrosine kinase inhibitors (TKIs) resistance in renal cell carcinoma (RCC). Methods To establish a sunitinib resistant renal cell carcinoma cell line (786O-R) and screen out arachidonic acid 5-lipoxygenase (ALOX5), a key gene regulating lipid metabolism, by transcriptome sequencing. To explore...

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Literature Corpus work
f8b548f4-1bce-5130-abd2-a75adde8ad10
DOI
10.21203/rs.3.rs-9456354/v1
Open publication

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The ALOX5 inhibitor zileuton promotes sunitinib resistance in renal cell carcinoma by reprogramming lipid metabolismDOI 10.21203/rs.3.rs-9456354/v1
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