Article
m6A-mRNA Reader YTHDF2 Identified as a Potential Risk Gene in Autism With Disproportionate Megalencephaly.
Autism research : official journal of the International Society for Autism Research - 1 May 2025
Nishizaki Sierra S, Haghani Nicholas K, La Gabriana N, Mariano Natasha Ann F, Uribe-Salazar José M, Kaya Gulhan, Regester Melissa, Andrews Derek Sayre, Nordahl Christine Wu, Amaral David G, Dennis Megan Y
Abstract excerpt
Among autistic individuals, a subphenotype of disproportionate megalencephaly (ASD-DM) seen at three years of age is associated with co-occurring intellectual disability and poorer prognoses later in life. However, many of the genes contributing to ASD-DM have yet to be delineated. In this study, we identified additional ASD-DM candidate genes with the aim to better define the genetic etiology of this...
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- Humans
- Animals
- Megalencephaly
- Zebrafish
- Male
- Autistic Disorder