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Article

Fast and accurate imputation of genotypes from noisy low-coverage sequencing data in bi-parental populations.

PloS one - 1 Jan 2025

Triay Cécile, Boizet Alice, Fragoso Christopher, Gkanogiannis Anestis, Rami Jean-François, Lorieux Mathias

Abstract excerpt

MOTIVATION: Genotyping of bi-parental populations can be performed with low-coverage next-generation sequencing (LC-NGS). This allows the creation of highly saturated genetic maps at reasonable cost, precisely localized recombination breakpoints (i.e., the crossovers), and minimized mapping intervals for quantitative-trait locus analysis. The main issues with these low-coverage genotyping methods are (1) poor...

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Topics

Algorithms
High-Throughput Nucleotide Sequencing
Genotype
Humans
Quantitative Trait Loci
Software

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Recombination, Genetic

Source

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Identifiers

PMID: 39883620
DOI: 10.1371/journal.pone.0314759
PMCID: PMC11781708

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