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The genetics of neurodegenerative diseases is the genetics of age-related damage clearance failure

29 Jan 2025

Abstract excerpt

In this perspective we draw together the data from the genome wide association studies for Alzheimer's disease, Parkinson's disease and the tauopathies and reach the conclusion that in each case, most of the risk loci are involved in the clearance of the deposited proteins: in Alzheimer's disease, the microglial removal of Aβ, in the synucleinopathies, the lysosomal clearance of synuclein and in the tauopathies,...

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PMID: 39880902
DOI: 10.1038/s41380-025-02911-7

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