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Fetal Fibroblast Heterogeneity Defines Dermal Architecture during Human Embryonic Skin Development

27 Jan 2025

Abstract excerpt

To investigate the heterogeneity of fibroblasts in human fetal skin, we analyzed published single-cell RNA-sequencing data (7 and 16 weeks after conception) and performed single-molecule FISH to map their spatial distribution and predicted dynamic interactions. Clustering revealed 8 fibroblast populations with changes in developmental stage-specific abundance. Proliferative cells (MKI67+) were present at all...

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PMID: 39880186
DOI: 10.1016/j.jid.2024.12.027

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