Article
Discovery of a MET -driven monogenic cause of steatotic liver disease.
Hepatology (Baltimore, Md.) - 1 Dec 2025
Pinto E Vairo Filippo, Zimmermann Michael T, Wagenknecht Jessica, Jorge Salomão Doria, Tian Shulan, Vierkant Robert A, Luehrs Anthony C, Milech de Assunção Thiago, Mathison Angela, Atwal Paldeep S, Cao Yang, Allen Alina M, Klee Eric W, Urrutia Raul, Lazaridis Konstantinos N
Abstract excerpt
BACKGROUND AND AIMS: Metabolic dysfunction-associated steatotic liver disease affects about a third of adults worldwide and is projected soon to be the leading cause of liver cirrhosis. It occurs when fat accumulates in hepatocytes and can progress to metabolic dysfunction-associated steatohepatitis, liver cirrhosis, and HCC. Metabolic dysfunction-associated steatotic liver disease pathogenesis is believed to...
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- Adult
- Female
- Humans
- Male
- Middle Aged
- Exome Sequencing