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Article

Genetic Mediators of Celiac Disease and Premature Ovarian Failure: Hypothyroidism and Systemic Lupus Erythematosus.

American journal of reproductive immunology (New York, N.Y. : 1989) - 1 Feb 2025

Hou Yuxi, Song Weihong, Wei Guoguo, Mo Yuanhang, Zhang Manna, Chen Xiaohu, Cao Chunge, Yue Chaoyan, Shao Xiaowen

Abstract excerpt

BACKGROUND: Observational studies suggested celiac disease (CD) possibly be a risk factor for premature ovarian failure (POF). However, causality remains unclear. And hypothyroidism and systemic lupus erythematosus may be the mediating factors. METHODS: We performed 2-sample Mendelian randomization (2SMR) to infer a causal relationship between CD and POF using genome-wide association study summary data obtained...

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Share to Celiac Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypothyroidism

Share to Lupus Erythematosus, Systemic

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 39871723
DOI: 10.1111/aji.70038

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