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Article

Causal relationship between hypothyroidism and ulcerative colitis: a bidirectional Mendelian randomization study.

BMC gastroenterology - 30 Oct 2024

Yang Yumeng, Li Jianhui, Wang Xin, Ma Jing

Abstract excerpt

OBJECTIVE: Ulcerative colitis (UC) and Hashimoto's thyroiditis frequently cooccur in patients with multiple autoimmune conditions, but the specific association between UC and hypothyroidism is unknown. We used Mendelian randomization (MR) methods to determine the causal relationship between UC and hypothyroidism. METHODS: We obtained single nucleotide polymorphisms (SNPs) related to ulcerative colitis (UC) and...

Topics

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Causality
Colitis, Ulcerative
Genetic Predisposition to Disease
Genome-Wide Association Study
Hypothyroidism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Polymorphism, Single Nucleotide

STAT4 Transcription Factor

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Identifiers

PMID: 39478467
DOI: 10.1186/s12876-024-03461-y
PMCID: PMC11526713

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