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Article

Primary ovarian insufficiency consequence of autoimmune diseases: a bidirectional two-sample Mendelian randomization study.

Frontiers in endocrinology - 1 Jan 2024

Du Yongming, Hu Yichao, Sheng Yuehua, Zhu Tianhong, Liu Shenping, Ding Huiqing, Guan Yutao

Abstract excerpt

Background: Observational studies suggest the risk of primary ovarian insufficiency (POI) is increased in autoimmune disorders (AIDs), but it is unclear whether there is a causal relationship. Therefore, we aimed to investigate the bidirectional causality between 20 AIDs and POI using Mendelian randomization (MR) analysis. Methods: A bidirectional two-sample MR investigation was designed by using publicly...

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Autoimmune Diseases
Genetic Predisposition to Disease
Genome-Wide Association Study
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Primary Ovarian Insufficiency

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PMID: 39717103
DOI: 10.3389/fendo.2024.1417896
PMCID: PMC11663653

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