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Article

Surveying helix 12 dynamics within constitutively active estrogen receptors using bipartite tetracysteine display.

The Journal of biological chemistry - 1 Mar 2025

Sendanayake Lasantha R, Pokhrel Ranju, Holub Justin M

Abstract excerpt

Somatic Y537S and D538G mutations within the estrogen receptor alpha ligand-binding domain (ERα-LBD) have been linked to enhanced cell proliferation, survival, and metastases in ER-positive breast cancers. Such mutations are thought to confer ligand-independent receptor activation by increasing the flexibility of helix 12 (H12), a segment within the ERα-LBD that acts as a dynamic regulator of ERα activity. We...

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Identifiers

PMID: 39864623
DOI: 10.1016/j.jbc.2025.108231
PMCID: PMC11889964

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