Breast cancer outcomes after skin- and nipple-sparing mastectomy in BRCA pathogenic mutation carriers versus non-BRCA carriers.

doi:10.1016/j.radonc.2025.110710

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Article

Breast cancer outcomes after skin- and nipple-sparing mastectomy in BRCA pathogenic mutation carriers versus non-BRCA carriers.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 Apr 2025

Moshe Nir, Haisraely Ory, Globus Ofer, Faermann Renata, Abu-Shehada Narmeen, Anaby Debbie, Gal Yam Einav, Balint Lahat Nora, Galper Shira, Menes Tehillah, Haik Josef, Sklair-Levy Miri, Oedegaard Cecille, Kuehn Thorsten, Morrow Monica, Poortmans Philip, Bernstein-Molho Rinat, Kaidar-Person Orit

Abstract excerpt

Our previous study on breast cancer BRCA carriers disclosed a high local recurrence (LR) rate in patients who underwent skin sparing (SSM) or nipple sparing mastectomy (NSM) without postoperative radiation therapy (RT), compared to breast conservation surgery or mastectomy with RT. The current study compares the LR rates in BRCA versus non BRCA carriers after SSM/NSM in relation the receipt of RT. METHODS: The...

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PMID: 39862923
DOI: 10.1016/j.radonc.2025.110710

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