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Genome-wide methylation sequencing identifies progression-related epigenetic drivers in myelodysplastic syndromes

20 Nov 2020

Abstract excerpt

The potential mechanism of myelodysplastic syndromes (MDS) progressing to acute myeloid leukemia (AML) remains poorly elucidated. It has been proved that epigenetic alterations play crucial roles in the pathogenesis of cancer progression including MDS. However, fewer studies explored the whole-genome methylation alterations during MDS progression. Reduced representation bisulfite sequencing was conducted in four...

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PMID: 33219204
DOI: 10.1038/s41419-020-03213-2

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