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A genome-wide association study identified PRKCB as a causal gene and therapeutic target for Mycobacterium avium complex disease

22 Jan 2025

Abstract excerpt

Non-tuberculous mycobacterial pulmonary disease (NTM-PD) is a chronic progressive lung disease that is increasing in incidence. Host genetic factors are associated with NTM-PD susceptibility. However, the heritability of NTM-PD is not well understood. Here, we perform a two-stage genome-wide association study (GWAS) and discover a susceptibility locus at 16p21 associated with NTM-PD, especially with pulmonary...

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PMID: 39848245
DOI: 10.1016/j.xcrm.2024.101923

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