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Article

Novel protein pathways in development and progression of pulmonary sarcoidosis.

Scientific reports - 6 Aug 2020

Bhargava Maneesh, Viken K J, Barkes B, Griffin T J, Gillespie M, Jagtap P D, Sajulga R, Peterson E J, Dincer H E, Li L, Restrepo C I, O'Connor B P, Fingerlin T E, Perlman D M, Maier L A

Abstract excerpt

Pulmonary involvement occurs in up to 95% of sarcoidosis cases. In this pilot study, we examine lung compartment-specific protein expression to identify pathways linked to development and progression of pulmonary sarcoidosis. We characterized bronchoalveolar lavage (BAL) cells and fluid (BALF) proteins in recently diagnosed sarcoidosis cases. We identified 4,306 proteins in BAL cells, of which 272 proteins were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32764642
DOI: 10.1038/s41598-020-69281-8
PMCID: PMC7413390

Genes

CD28
PFKFB4
PTEN

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