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Article

Alternative driver pathways in peripheral nerve sheath tumors - including DICER1 and/or KRAS alterations.

The Journal of pathology - 1 Mar 2025

Chang Hsin-Yi, Saoud Carla, Torrence Dianne, Tap William, Chi Ping, Antonescu Cristina R

Abstract excerpt

DICER1-associated sarcoma is an emerging entity, defined by either somatic or germline dicer 1, ribonuclease III (DICER1) mutations and sharing characteristic morphologic features irrespective of the site of origin. In addition to the DICER1 driver mutation, concurrent genomic alterations, including tumor protein 53 (TP53) inactivation and RAS pathway activation, are frequently detected. Tumors that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39846292
DOI: 10.1002/path.6391
PMCID: PMC12247263

Genes

DICER1
KRAS
ATRX
TP53
NF1
NF2

Variants

Provenance

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