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Attenuating the endoplasmic reticulum stress response improves functional recovery after spinal cord injury

2 Jun 2011

Abstract excerpt

Activation of the unfolded protein response (UPR) is involved in the pathogenesis of numerous CNS myelin abnormalities; yet, its direct role in traumatic spinal cord injury (SCI)-induced demyelination is not known. The UPR is an evolutionarily conserved cell defense mechanism initiated to restore endoplasmic reticulum homeostasis in response to various cellular stresses including infection, trauma, and oxidative...

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PMID: 21638341
DOI: 10.1002/glia.21191

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