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The Epstein-Barr virus deubiquitinase BPLF1 regulates stress-induced ribosome UFMylation and reticulophagy

22 Jan 2025

Abstract excerpt

The synthesis of membrane and secreted proteins is safeguarded by an endoplasmic reticulum-associated ribosome quality control (ER-RQC) that promotes the disposal of defective translation products by the proteasome or via a lysosome-dependent pathway involving the degradation of portions of the ER by macroautophagy (reticulophagy). The UFMylation of RPL26 on ER-stalled ribosomes is essential for activating the...

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PMID: 39842454
DOI: 10.1080/15548627.2024.2440846

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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