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Aberrant acetylation caused by a CDYL splicing mutation contributes to thin mid-piece related asthenoteratozoospermia and male infertility.

Andrology - 1 Nov 2025

Yang Fan, Gao Yang, Han Bing, Zhu Wen, Wang Guanxiong, Liu Liting, Shen Qunshan, Song Bing, Lv Mingrong, Wu Huan, Tang Dongdong, Zhou Ping, Wei Zhaolian, Xu Yuping, Cao Yunxia, He Xiaojin

Abstract excerpt

OBJECTIVES: Acetylated tubulin is a hallmark of flagellar stability in spermatozoa, and studies have demonstrated the ability of CDYL to function as a tubulin acetyltransferase in spermatozoa. Of note, germline conditional knockout of Cdyl can lead to asthenoteratozoospermia and infertility in male mice. However, the role of CDYL gene in human fertility remains uncharacterized. MATERIALS AND METHODS: Data were...

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Identifiers

PMID: 39823157
DOI: 10.1111/andr.13825

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CDYL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Aberrant acetylation caused by a CDYL splicing mutation contributes to thin mid-piece related asthenoteratozoospermia and male infertility.PMID 39823157Read ↗

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