Article
Comprehensive in silico analysis of single nucleotide polymorphism and molecular dynamics simulation of human GATA6 protein in ventricular septal defect.
Narra J - 1 Dec 2024
Hidayat Taufiq, Irwanto Irwanto, Rohman Ali, Muhyiddin Afrizal Aa, Putri Safira Na, Kurniawan Dedy B, Syaban Mokhamad Fr, Firdaus Theakirana, Rahman Mahrus A, Utamayasa I Ka
Abstract excerpt
Congenital heart disease (CHD) represents nearly one-third of congenital birth defects annually, with ventricular septal defect (VSD) being the most common type. The aim of this study was to explore the role of specific GATA binding protein 6 gene (GATA6) mutations as a potential etiological factor in the development of VSD through an in silico approach. Data were collected from the human gene databases: DisGeNET...
Read the complete abstract on PubMedTopics
- Humans
- GATA6 Transcription Factor
- Polymorphism, Single Nucleotide
- Heart Septal Defects, Ventricular
- Molecular Dynamics Simulation