Article
Novel GATA4 mutations in patients with congenital ventricular septal defects.
Medical science monitor : international medical journal of experimental and clinical research - 1 Jun 2012
Yang Yi-Qing, Wang Juan, Liu Xing-Yuan, Chen Xiao-Zhong, Zhang Wei, Wang Xiao-Zhou, Liu Xu, Fang Wei-Yi
Abstract excerpt
BACKGROUND: Ventricular septal defect (VSD) is the most prevalent type of congenital heart disease and is a major cause of substantial morbidity and mortality in infants. Accumulating evidence implicates genetic defects, especially in cardiac transcription factors, in the pathogenesis of VSD. However, VSD is genetically heterogeneous and the genetic determinants for VSD in most patients remain to be identified....
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