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Total functioning capacity scale in Huntington's disease: natural course over time

15 Jan 2025

Abstract excerpt

BACKGROUND AND OBJECTIVES: The total functioning capacity (TFC) assessment has been integral to Huntington's disease (HD) research and clinical trials, measuring disease stage and progression. This study investigates the natural progression of function in HD, focusing on changes in TFC scores related to age and CAG-repeat length, and evaluates TFC's strengths and weaknesses in longitudinal studies. METHODS: Using...

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PMID: 39812810
DOI: 10.1007/s00415-024-12771-w

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