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Article

Genetic predisposition to altered blood cell homeostasis is associated with glioma risk and survival.

Nature communications - 14 Jan 2025

Kachuri Linda, Guerra Geno A, Nakase Taishi, Wendt George A, Hansen Helen M, Molinaro Annette M, Bracci Paige, McCoy Lucie, Rice Terri, Wiencke John K, Eckel-Passow Jeanette E, Jenkins Robert B, Wrensch Margaret, Francis Stephen S

Abstract excerpt

Glioma is a highly fatal and heterogeneous brain tumor with few known risk factors. Our study examines genetically predicted variability in blood cell indices in relation to glioma risk and survival in 3418 cases and 8156 controls. We find that increased platelet to lymphocyte ratio (PLR) confers an increased risk of glioma (odds ratio (OR) = 1.25, p = 0.005), especially tumors with isocitrate dehydrogenase (IDH)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39809742
DOI: 10.1038/s41467-025-55919-6
PMCID: PMC11732991

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