Article
Proteomic profile in glomeruli of type-2 diabetic KKAy mice using 2-dimensional differential gel electrophoresis.
Medical science monitor : international medical journal of experimental and clinical research - 17 Dec 2014
Liu Xiaodan, Yang Gang, Fan Qiuling, Wang Lining
Abstract excerpt
BACKGROUND: Diabetic nephropathy (DN) is a leading cause of end-stage renal disease. To search for glomerular proteins associated with early-stage DN, glomeruli of spontaneous type 2 diabetic KKAy mice were analyzed by 2-dimensional differential gel electrophoresis (2D-DIGE). MATERIAL AND METHODS: Glomeruli of 20-week spontaneous type 2 diabetic KKAy mice and age-matched C57BL/6 mice were isolated by kidney...
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