Article
Whole-genome and transcriptome analysis enhances precision cancer treatment options.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Sept 2022
Pleasance E, Bohm A, Williamson L M, Nelson J M T, Shen Y, Bonakdar M, Titmuss E, Csizmok V, Wee K, Hosseinzadeh S, Grisdale C J, Reisle C, Taylor G A, Lewis E, Jones M R, Bleile D, Sadeghi S, Zhang W, Davies A, Pellegrini B, Wong T, Bowlby R, Chan S K, Mungall K L, Chuah E, Mungall A J, Moore R A, Zhao Y, Deol B, Fisic A, Fok A, Regier D A, Weymann D, Schaeffer D F, Young S, Yip S, Schrader K, Levasseur N, Taylor S K, Feng X, Tinker A, Savage K J, Chia S, Gelmon K, Sun S, Lim H, Renouf D J, Jones S J M, Marra M A, Laskin J
Abstract excerpt
BACKGROUND: Recent advances are enabling delivery of precision genomic medicine to cancer clinics. While the majority of approaches profile panels of selected genes or hotspot regions, comprehensive data provided by whole-genome and transcriptome sequencing and analysis (WGTA) present an opportunity to align a much larger proportion of patients to therapies. PATIENTS AND METHODS: Samples from 570 patients with...
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