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Clinical interpretation of whole-genome and whole-transcriptome sequencing for precision oncology.

Seminars in cancer biology - 1 Sept 2022

Jobanputra Vaidehi, Wrzeszczynski Kazimierz O, Buttner Reinhard, Caldas Carlos, Cuppen Edwin, Grimmond Sean, Haferlach Torsten, Mullighan Charles, Schuh Anna, Elemento Olivier

Abstract excerpt

Whole-genome sequencing either alone or in combination with whole-transcriptome sequencing has started to be used to analyze clinical tumor samples to improve diagnosis, provide risk stratification, and select patient-specific therapies. Compared with current genomic testing strategies, largely focused on small number of genes tested individually or targeted panels, whole-genome and transcriptome sequencing...

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Cancer Genomics and Diagnostics
Genome
High-Throughput Nucleotide Sequencing
Medical Oncology
Mutation

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Precision Medicine

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PMID: 34256129
DOI: 10.1016/j.semcancer.2021.07.003

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