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Article

Senescence-related Genes as Prognostic Markers for STEMI Patients: LASSO Regression-Based Bioinformatics and External Validation.

Journal of cardiovascular translational research - 1 Apr 2025

Wang Xing-Jie, Huang Lei, Hou Min, Guo Jie

Abstract excerpt

The prognostic value of differentially expressed senescence-related genes(DESRGs) in ST-segment elevation myocardial infarction(STEMI) patients is unclear. We used GEO2R to identify DESRGs from GSE60993 and performed functional enrichment analysis. We built an optimal prognostic model with LASSO penalized Cox regression via GSE49925. We evaluated the model with survival analysis, ROC curve, decision curve...

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PMID: 39786668
DOI: 10.1007/s12265-024-10583-x

Genes

CDC25B
ECHDC3
FKBP5

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