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Immune complexes-mediated activation of neutrophils in systemic lupus erythematosus is dependent on RNA recognition by toll-like receptor 8

24 Dec 2024

Abstract excerpt

Introduction: Neutrophil activation is important in systemic lupus erythematosus (SLE). We previously demonstrated that ribonucleoprotein (RNP) immune complexes (ICs) promoted neutrophil activation in a TLR7/8-dependent manner. However, it remains unclear if this mechanism occurs in patients. Here, we investigated the role of RNA recognition by evaluating TLR7/8 in plasma-mediated neutrophil activation in SLE....

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Share to Immune Response and Inflammation
Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39776899
DOI: 10.3389/fimmu.2024.1515469

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