Predictive Efficacy of Dual Therapies Combining Integrase Strand Transfer Inhibitors with Second-Generation Non-Nucleoside Reverse Transcriptase Inhibitors Following HIV-1 Treatment Failure in Cameroon: Implications for the Use of a Long-Acting Therapeutic Strategy in Low- and Middle-Income Countries.

doi:10.3390/v16121853

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Predictive Efficacy of Dual Therapies Combining Integrase Strand Transfer Inhibitors with Second-Generation Non-Nucleoside Reverse Transcriptase Inhibitors Following HIV-1 Treatment Failure in Cameroon: Implications for the Use of a Long-Acting Therapeutic Strategy in Low- and Middle-Income Countries.

Viruses - 29 Nov 2024

Gouissi Anguechia Davy-Hyacinthe, Bouba Yagai, Semengue Ezechiel Ngoufack Jagni, Ka'e Aude Christelle, Takou Désiré, Ambe Chenwi Collins, Beloumou Grace, Nka Alex Durand, Basseck Wome Ulrich Roland, Santoro Maria Mercedes, Ceccherini-Silberstein Francesca, Chatté Adawaye, Montesano Carla, Cappelli Giulia, Colizzi Vittorio, Ndjolo Alexis, Mbanya Dora, Ndembi Nicaise, Perno Carlo-Federico, Fokam Joseph

Abstract excerpt

Dual therapies (DT) combining integrase strand transfer inhibitors (INSTIs) with second-generation non-nucleoside reverse transcriptase inhibitors (2nd-Gen-NNRTIs) offer new possibilities for HIV treatment to improve adherence. However, drug resistance associated mutations (RAMs) to prior antiretrovirals may jeopardize the efficacy of DT. We herein describe the predicted efficacy of DT combining INSTIs +...

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PMID: 39772163
DOI: 10.3390/v16121853

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Predictive Efficacy of Dual Therapies Combining Integrase Strand Transfer Inhibitors with Second-Generation Non-Nucleoside Reverse Transcriptase Inhibitors Following HIV-1 Treatment Failure in Cameroon: Implications for the Use of a Long-Acting Therapeutic Strategy in Low- and Middle-Income Countries.PMID 39772163Read ↗

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