BRCA testing in metastatic castration-resistant prostate cancer: successes and troubles in a real world setting. An Italian Multicentric study.

doi:10.32074/1591-951X-1010

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Article

BRCA testing in metastatic castration-resistant prostate cancer: successes and troubles in a real world setting. An Italian Multicentric study.

Pathologica - 1 Oct 2024

Tommasi Stefania, Coppola Claudio Antonio, Caniglia Alessandro, Pilato Brunella, Zito Francesco Alfredo, Carosi Mariantonia, Melucci Elisa, Casini Beatrice, Russo Andrea, Gismondi Viviana, Cirmena Gabriella, Paudice Michele, Malapelle Umberto, Pepe Francesco, Troncone Giancarlo, Fontanini Gabriella, Bruno Rossella, Faviana Pinuccia, Vacirca Davide, Taormina Sergio Vincenzo, Francesconi Simona, Caprera Cecilia, Corsi Matteo, Bracarda Sergio, Barberis Massimo

Abstract excerpt

Objective: Prostate cancer (PCa) is the most common cause of cancer-related deaths in men worldwide. BRCA1/2 genes are reported altered in approximately 1% and 8% of PCa cases, respectively. To date, formalin-fixed paraffin-embedded (FFPE) tissues have a consolidate use in the clinical practice, but with a significant drawback related to DNA/RNA degradation during the pre-analytical process. The purpose of this...

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PMID: 39748712
DOI: 10.32074/1591-951X-1010

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