Systematic surveillance of SARS-CoV-2 reveals dynamics of variant mutagenesis and transmission in a large urban population.

doi:10.1038/s41467-024-55031-1

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Article

Systematic surveillance of SARS-CoV-2 reveals dynamics of variant mutagenesis and transmission in a large urban population.

Nature communications - 30 Dec 2024

Aynaud Marie-Ming, Caldwell Lauren, Al-Zahrani Khalid N, Barutcu Seda, Chan Kin, Obersterescu Andreea, Ogunjimi Abiodun A, Jin Min, Zakoor Kathleen-Rose, Patel Shyam, Padilla Ron, Jen Mark C C, Veniegas Princess Mae, Dewsi Nursrin, Yonathan Filiam, Zhang Lucy, Ayson-Fortunato Amelia, Aquino Analiza, Krzyzanowski Paul, Simpson Jared, Bartlett John, Lungu Ilinca, Wouters Bradly G, Rini James M, Gekas Michael, Poutanen Susan, Pelletier Laurence, Mazzulli Tony, Wrana Jeffrey L

Abstract excerpt

Highly mutable pathogens generate viral diversity that impacts virulence, transmissibility, treatment, and thwarts acquired immunity. We previously described C19-SPAR-Seq, a high-throughput, next-generation sequencing platform to detect SARS-CoV-2 that we here deployed to systematically profile variant dynamics of SARS-CoV-2 for over 3 years in a large, North American urban environment (Toronto, Canada)....

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PMID: 39738001
DOI: 10.1038/s41467-024-55031-1
PMCID: PMC11685962

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