Single-nuclei RNA-sequencing fails to detect molecular dysregulation in the preeclamptic placenta

Abstract excerpt

INTRODUCTION: Single-cell RNA-seq (scRNA-seq) revolutionized our understanding of tissue complexity in health and disease and revealed massive transcriptional dysregulation across placental cell classes in early-onset, but not late-onset preeclampsia (PE). However, the multinucleated syncytium is largely inaccessible to cell dissociation. Nuclei isolation and single-nuclei RNA-seq may be preferable in the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Maternal and fetal healthcare
• Share to Pregnancy and preeclampsia studies
• Share to Single-cell and spatial transcriptomics