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A conserved pilin from uncultured gut bacterial clade TANB77 enhances cancer immunotherapy

27 Dec 2024

Abstract excerpt

Immune checkpoint blockade (ICB) has become a standard anti-cancer treatment, offering durable clinical benefits. However, the limited response rate of ICB necessitates biomarkers to predict and modulate the efficacy of the therapy. The gut microbiome’s influence on ICB efficacy is of particular interest due to its modifiability through various interventions. However, gut microbiome biomarkers for ICB response...

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PMID: 39730328
DOI: 10.1038/s41467-024-55388-3

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