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Custom scoring based on ecological topology of gut microbiota associated with cancer immunotherapy outcome

1 Jun 2024

Abstract excerpt

The gut microbiota influences the clinical responses of cancer patients to immunecheckpoint inhibitors (ICIs). However, there is no consensus definition of detrimental dysbiosis. Based on metagenomics (MG) sequencing of 245 non-small cell lung cancer (NSCLC) patient feces, we constructed species-level co-abundance networks that were clustered into species-interacting groups (SIGs) correlating with overall...

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PMID: 38906102
DOI: 10.1016/j.cell.2024.05.029

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