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Article

NRIR promotes immune escape in hepatocellular cancer by regulating IFNγ-induced PD-L1 expression

27 Feb 2025

Abstract excerpt

• HCC has a complex mechanism of immune escape and tumour progression. • The mechanisms by which NRIR regulates PD-L1 in cancer, particularly in HCC, remain incompletely understood. • NRIR could upregulate the expression of PD-L1 and suppress the cytotoxicity of T cells in HCC by regulating the IFNγ signaling pathway. • The NRIR-CMPK2-IFNγ-PD-L1 axis may be a novel lncRNA-mediated mechanism and therapeutic target...

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PMID: 40023249
DOI: 10.1016/j.jare.2025.02.034

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