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Article

Myeloid landscape of BRAF-mutant papillary thyroid cancer and thyroiditis.

Endocrine-related cancer - 1 Aug 2026

Perampalam Sumathy, Gild Matti, Sey Adwoa Amoakowa, Tacon Lyndal J, Fadia Mitali, King Cathal, Papachristos Alexander, Sywak Mark, Gill Anthony J, Bullock Martyn, Clifton-Bligh Roderick J

Abstract excerpt

Papillary thyroid cancer (PTC) is less aggressive when associated with lymphocytic thyroiditis (LT), even in the presence of oncogenic BRAF, including smaller tumours, less lymph node involvement and reduced extrathyroidal extension. To investigate possible immune mechanisms underlying this association, we compared the tumour microenvironment of PTC-BRAF with LT and that without LT using single-cell RNA...

Read the complete abstract on PubMed

Topics

Humans
Proto-Oncogene Proteins B-raf
Thyroid Neoplasms
Thyroid Cancer, Papillary
Mutation
Tumor Microenvironment

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Myeloid Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 42583701
DOI: 10.1530/ERC-26-0088
PMCID: PMC13539360

Genes

BRAF
ECRG4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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