Basement membranes are crucial for proper olfactory placode shape, position and boundary with the brain, and for olfactory axon development.

Abstract excerpt

Despite recent progress, the complex roles played by the extracellular matrix in development and disease are still far from being fully understood. Here, we took advantage of the zebrafish sly mutation which affects Laminin γ1, a major component of basement membranes, to explore its role in the development of the olfactory system. Following a detailed characterisation of Laminin distribution in the developing...

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