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Indole-3-lactic acid derived from tryptophan metabolism alleviates the sFlt-1-induced preeclampsia-like phenotype via the activation of aryl hydrocarbon receptor.

Life sciences - 15 Jan 2025

Wei Yingying, Tian Haojun, Peng Hao, Wubulikasimu Ayinisa, Wei Mengtian, Li Han, He Qizhi, Duan Tao, Huang Yiying, Wang Kai

Abstract excerpt

AIMS: Preeclampsia (PE) is an unusual multisystem condition that occurs during pregnancy and is characterized by maternal endothelial dysfunction and damage to various organs. The catabolism of L-tryptophan (Trp) is involved in various biological activities, including healthy pregnancy. Our previous work revealed that PE significantly elevated the concentration of indole-3-lactic acid (ILA), a Trp derivative,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39710059
DOI: 10.1016/j.lfs.2024.123329

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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