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Pathological shifts in tryptophan metabolism in human term placenta exposed to LPS or poly I:C

21 Dec 2023

Abstract excerpt

Maternal immune activation during pregnancy is a risk factor for offspring neuropsychiatric disorders. Among the mechanistic pathways by which maternal inflammation can affect fetal brain development and programming, those involving tryptophan (TRP) metabolism have drawn attention because various TRP metabolites have neuroactive properties. This study evaluates the effect of bacterial (lipopolysaccharides/LPS)...

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PMID: 38145492
DOI: 10.1093/biolre/ioad181

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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