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Two highly selected mutations in the tandemly duplicated CYP6P4a and CYP6P4b genes drive pyrethroid resistance in Anopheles funestus in West Africa.

BMC biology - 18 Dec 2024

Tatchou-Nebangwa Nelly M T, Mugenzi Leon M J, Muhammad Abdullahi, Nebangwa Derrick N, Kouamo Mersimine F M, Tagne Carlos S Djoko, Tekoh Theofelix A, Tchouakui Magellan, Ghogomu Stephen M, Ibrahim Sulaiman S, Wondji Charles S

Abstract excerpt

BACKGROUND: Gaining a comprehensive understanding of the genetic mechanisms underlying insecticide resistance in malaria vectors is crucial for optimising the effectiveness of insecticide-based vector control methods and developing diagnostic tools for resistance management. Considering the heterogeneity of metabolic resistance in major malaria vectors, the implementation of tailored resistance management...

Topics

Animals
Anopheles
Pyrethrins
Insecticide Resistance
Mutation
Africa, Western
Insecticides
Mosquito Vectors
Insect Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39696366
DOI: 10.1186/s12915-024-02081-y
PMCID: PMC11657943

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Two highly selected mutations in the tandemly duplicated CYP6P4a and CYP6P4b genes drive pyrethroid resistance in Anopheles funestus in West Africa.PMID 39696366Read ↗

Two highly selected mutations in the tandemly duplicated <i>CYP6P4a</i> and <i>CYP6P4b</i> drive pyrethroid resistance in <i>Anopheles funestus</i>Semantic proximity Read ↗

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