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Article

Two highly selected mutations in the tandemly duplicated CYP6P4a and CYP6P4b genes drive pyrethroid resistance in Anopheles funestus in West Africa.

BMC biology - 18 Dec 2024

Tatchou-Nebangwa Nelly M T, Mugenzi Leon M J, Muhammad Abdullahi, Nebangwa Derrick N, Kouamo Mersimine F M, Tagne Carlos S Djoko, Tekoh Theofelix A, Tchouakui Magellan, Ghogomu Stephen M, Ibrahim Sulaiman S, Wondji Charles S

Abstract excerpt

BACKGROUND: Gaining a comprehensive understanding of the genetic mechanisms underlying insecticide resistance in malaria vectors is crucial for optimising the effectiveness of insecticide-based vector control methods and developing diagnostic tools for resistance management. Considering the heterogeneity of metabolic resistance in major malaria vectors, the implementation of tailored resistance management...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39696366
DOI: 10.1186/s12915-024-02081-y
PMCID: PMC11657943

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Two highly selected mutations in the tandemly duplicated CYP6P4a and CYP6P4b genes drive pyrethroid resistance in Anopheles funestus in West Africa.PMID 39696366Read ↗

Two highly selected mutations in the tandemly duplicated <i>CYP6P4a</i> and <i>CYP6P4b</i> drive pyrethroid resistance in <i>Anopheles funestus</i>Semantic proximity Read ↗

Allelic Variation of Cytochrome P450s Drives Resistance to Bednet Insecticides in a Major Malaria Vector.Semantic proximity Read ↗

A single mutation G454A in the P450 CYP9K1 drives pyrethroid resistance in the major malaria vector Anopheles funestus reducing bed net efficacy.Semantic proximity Read ↗

A single mutation G454A in P450 <i>CYP9K1</i> drives pyrethroid resistance in the major malaria vector <i>Anopheles funestus</i> reducing bed net efficacySemantic proximity Read ↗

Association of a rapidly selected 4.3kb transposon-containing structural variation with a P450-based resistance to pyrethroids in the African malaria vector Anopheles funestusSemantic proximity Read ↗

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Directionally selected cytochrome P450 alleles are driving the spread of pyrethroid resistance in the major malaria vector Anopheles funestus.Semantic proximity Read ↗

Multi‐omics analysis identifies a CYP9K1 haplotype conferring pyrethroid resistance in the malaria vector Anopheles funestus in East AfricaSemantic proximity Read ↗

The highly polymorphic CYP6M7 cytochrome P450 gene partners with the directionally selected CYP6P9a and CYP6P9b genes to expand the pyrethroid resistance front in the malaria vector Anopheles funestus in Africa.Semantic proximity Read ↗

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Identification of a rapidly-spreading triple mutant for high-level metabolic insecticide resistance in Anopheles gambiae provides a real-time molecular diagnostic for anti-malarial intervention deployment.Semantic proximity Read ↗

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